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Article

Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Mar 2018

Topalis Dimitri, Gillemot Sarah, Snoeck Robert, Andrei Graciela

Abstract excerpt

Herpesviruses thymidine kinase (TK) and protein kinase (PK) allow the activation of nucleoside analogues used in anti-herpesvirus treatments. Mutations emerging in these two genes often lead to emergence of drug-resistant strains responsible for life-threatening diseases in immunocompromised populations. In this review, we analyze the binding of different nucleoside analogues to the TK active site of the three...

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Identifiers

PMID: 29548479
DOI: 10.1016/j.drup.2018.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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