Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.

Antimicrobial agents and chemotherapy - 1 Feb 2011

Piret Jocelyne, Boivin Guy

Abstract excerpt

Herpes simplex viruses (HSV) type 1 and type 2 are responsible for recurrent orolabial and genital infections. The standard therapy for the management of HSV infections includes acyclovir (ACV) and penciclovir (PCV) with their respective prodrugs valacyclovir and famciclovir. These compounds are phosphorylated by the viral thymidine kinase (TK) and then by cellular kinases. The triphosphate forms selectively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyclovir
Share to Drug Resistance, Viral
Share to Guanine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Herpes Simplex

Share to Herpesvirus 1, Human

Share to Herpesvirus 2, Human

Share to Nucleosides

Share to Viral Plaque Assay

Source

Open in PubMed Open full text

Identifiers

PMID: 21078929
DOI: 10.1128/AAC.00615-10
PMCID: PMC3028810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.PMID 21078929Read ↗

Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms.Semantic proximity Read ↗

Herpes simplex virus resistance to antiviral drugs.Semantic proximity Read ↗

Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients.Semantic proximity Read ↗

Testing of herpes simplex virus for resistance to antiviral drugs.Semantic proximity Read ↗

Genotypic testing improves detection of antiviral resistance in human herpes simplex virus.Semantic proximity Read ↗

High prevalence but low clinical impact of acyclovir-resistant herpes simplex virus type 1 infections in patients with hematologic disorders.Semantic proximity Read ↗

Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades.Semantic proximity Read ↗

Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance.Semantic proximity Read ↗

Clinical and genotypic characteristics of antiviral-resistant herpes simplex virus 1 and 2 infections: a case series.Semantic proximity Read ↗

Surveillance of herpes simplex virus resistance to antivirals: a 4-year survey.Semantic proximity Read ↗

Resistance of herpes simplex viruses to acyclovir: an update from a ten-year survey in France.Semantic proximity Read ↗

Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.