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Article

Antiherpesvirus activities of two novel 4'-thiothymidine derivatives, KAY-2-41 and KAH-39-149, are dependent on viral and cellular thymidine kinases.

Antimicrobial agents and chemotherapy - 1 Aug 2014

Coen Natacha, Duraffour Sophie, Haraguchi Kazuhiro, Balzarini Jan, van den Oord Joost J, Snoeck Robert, Andrei Graciela

Abstract excerpt

The emergence of drug-resistant herpesviruses represents a significant problem in clinical practice, primarily in immunocompromised patients. Furthermore, effective antiviral therapies against gammaherpesvirus-associated diseases are lacking. Here, we present two thiothymidine derivatives, KAY-2-41 and KAH-39-149, with different spectra of antiviral activity from those of the reference antiherpetic drugs, showing...

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Identifiers

PMID: 24820089
DOI: 10.1128/AAC.02825-14
PMCID: PMC4136010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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