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Article

PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo.

The Journal of experimental medicine - 4 Jun 2018

Parisotto Maxime, Grelet Elise, El Bizri Rana, Dai Yongyuan, Terzic Julie, Eckert Doriane, Gargowitsch Laetitia, Bornert Jean-Marc, Metzger Daniel

Abstract excerpt

Genetic ablation of the tumor suppressor PTEN in prostatic epithelial cells (PECs) induces cell senescence. However, unlike oncogene-induced senescence, no hyperproliferation phase and no signs of DNA damage response (DDR) were observed in PTEN-deficient PECs; PTEN loss-induced senescence (PICS) was reported to be a novel type of cellular senescence. Our study reveals that PTEN ablation in prostatic luminal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29743291
DOI: 10.1084/jem.20171207
PMCID: PMC5987915

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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