Article
A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension.
Journal of hypertension - 1 Aug 2007
Moreno María U, San José Gorka, Fortuño Ana, Beloqui Oscar, Redón Josep, Chaves Felipe J, Corella Dolores, Díez Javier, Zalba Guillermo
Abstract excerpt
OBJECTIVE: Oxidative stress is implicated in hypertension and the NADPH oxidase systems constitute the main source of superoxide in vascular wall. We searched for new polymorphisms within the CYBA promoter, the human gene that encodes the p22phox protein, and studied their potential association with essential hypertension. DESIGN: A case-control study in a random sample of the general population. METHODS: CYBA...
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