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Article

Genetic polymorphisms of NAD(P)H oxidase: variation in subunit expression and enzyme activity.

The pharmacogenomics journal - 1 Aug 2008

Schirmer M, Hoffmann M, Kaya E, Tzvetkov M, Brockmöller J

Abstract excerpt

Genetic polymorphisms in superoxide-producing NAD(P)H oxidase have been linked to cardiovascular diseases including anthracycline-induced cardiotoxicity. We quantified NAD(P)H oxidase activity in granulocytes of 81 healthy Caucasian volunteers (in addition, 51 in an independent confirmatory study) by chemiluminescence using the luminol analogue L-012. Expression of CYBA, NCF4 and RAC2 coding for NAD(P)H oxidase...

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Share to Gene Expression Regulation, Enzymologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

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Source

Identifiers

PMID: 17684477
DOI: 10.1038/sj.tpj.6500467

Genes

CYBA
RAC2
NCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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