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Article

Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases.

PloS one - 1 Jan 2011

Calero Olga, Bullido María J, Clarimón Jordi, Frank-García Ana, Martínez-Martín Pablo, Lleó Alberto, Rey María Jesús, Rábano Alberto, Blesa Rafael, Gómez-Isla Teresa, Valdivieso Fernando, de Pedro-Cuesta Jesús, Ferrer Isidro, Calero Miguel

Abstract excerpt

Alzheimer's disease (AD) and Creutzfeldt-Jakob disease (CJD) represent two distinct clinical entities belonging to a wider group, generically named as conformational disorders that share common pathophysiologic mechanisms. It is well-established that the APOE ε4 allele and homozygosity at polymorphic codon 129 in the PRNP gene are the major genetic risk factors for AD and human prion diseases, respectively....

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Identifiers

PMID: 21799773
DOI: 10.1371/journal.pone.0022090
PMCID: PMC3140492

Genes

APOE
PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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