Article
Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E epsilon4.
Neuroreport - 17 Apr 2001
Ingelson M, Fabre S F, Lilius L, Andersen C, Viitanen M, Almkvist O, Wahlund L O, Lannfelt L
Abstract excerpt
The tau gene has an important role in frontotemporal dementia (FTD) as pathogenic mutations have been found in hereditary forms of the disease. Furthermore, a certain extended tau haplotype has been shown to increase the risk for progressive supranuclear palsy, corticobasal degeneration, Parkinson's disease and, in interaction with the apolipoprotein E (apoE) epsilon4 allele, Alzheimer's disease. By...
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