Article
Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females.
European journal of neurology - 1 Jun 2006
Porrello E, Monti M C, Sinforiani E, Cairati M, Guaita A, Montomoli C, Govoni S, Racchi M
Abstract excerpt
Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects both sexes, with a higher prevalence in women. Declining estrogen levels after menopause may render estrogen target neurons in the brain more susceptible to age or disease-related processes such as AD. To investigate the role of two single nucleotide polymorphisms in the first intron of the ER-alpha gene, denominated PvuII and XbaI,...
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