Article
Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II.
Journal of cellular physiology - 1 May 1993
Campain J A, Padmanabhan R, Hwang J, Gottesman M M, Pastan I
Abstract excerpt
The topoisomerase II inhibitor, VP-16 (etoposide), is an important component in many chemotherapeutic regimens. To characterize resistance to this drug, the human melanoma cell line, FEM-X, was selected in multiple steps with VP-16. To prevent the development of typical multidrug resistance, an i...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Cell Nucleus
- DNA Topoisomerases, Type II
- Drug Resistance
- Etoposide
- Humans
- Melanoma
- Membrane Glycoproteins
- Mutation
- Neoplasm Proteins