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Article

Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II.

Journal of cellular physiology - 1 May 1993

Campain J A, Padmanabhan R, Hwang J, Gottesman M M, Pastan I

Abstract excerpt

The topoisomerase II inhibitor, VP-16 (etoposide), is an important component in many chemotherapeutic regimens. To characterize resistance to this drug, the human melanoma cell line, FEM-X, was selected in multiple steps with VP-16. To prevent the development of typical multidrug resistance, an inhibitor of P-glycoprotein, the tiapamil analog, RO-11-2933, was added to the selections. The resultant clone FVP3 is...

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PMID: 8097746
DOI: 10.1002/jcp.1041550224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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