Article
The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy.
Developmental biology - 15 Mar 2007
Gomez Tara A, Banfield Kelley L, Trogler Dorothy M, Clarke Steven G
Abstract excerpt
The protein L-isoaspartyl-O-methyltransferase, coded by the pcm-1 gene in Caenorhabditis elegans, participates in the repair of age-damaged proteins. We tested the ability of pcm-1-deficient nematodes to survive starvation stress as developmentally-arrested L1 larvae. We found that pcm-1 mutant L1 larvae do not survive as well as wild-type L1 larvae when incubated in M9 medium without nutrients. We then tested...
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