The protein L-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response.

doi:10.1016/j.mad.2008.09.019

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Article

The protein L-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response.

Mechanisms of ageing and development - 1 Dec 2008

Gomez Tara A, Banfield Kelley L, Clarke Steven G

Abstract excerpt

The efficient use of nutrients is important in development and aging. In this study, we asked if the protein repair methyltransferase has a related or additional role in energy metabolism and stress response in the nematode Caenorhabditis elegans. Worms lacking the pcm-1 gene encoding this enzyme exhibit reduced longevity as SDS-isolated dauer larvae and as arrested L1 larvae under starvation stress, while...

Topics

Aging
Animals
Animals, Genetically Modified
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Cycle Proteins
DNA Primers
DNA, Helminth
Female
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Enzymologic

Genes, Helminth

Heat-Shock Response

Larva

Lipid Metabolism

Longevity

Male

Source

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Identifiers

PMID: 18977240
DOI: 10.1016/j.mad.2008.09.019
PMCID: PMC2605584

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