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Article

Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2009

Shimizu Ritsuko, Kobayashi Eri, Engel James Douglas, Yamamoto Masayuki

Abstract excerpt

Two GATA1-related leukemias have been described: one is an erythroleukemia that develops in mice as a consequence of diminished expression of wild-type GATA1, whereas the other is an acute megakaryoblastic leukemia (AMKL) that arises in Down syndrome children as a consequence of somatic N-terminal truncation (DeltaNT) of GATA1. We discovered that mice expressing the shortened GATA1 protein (DeltaNTR mice)...

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Source

Identifiers

PMID: 19682090
DOI: 10.1111/j.1365-2443.2009.01338.x

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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