GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia.

Abstract excerpt

Although physicians have known for many decades that children with Down syndrome are predisposed to developing transient myeloproliferative disorder (TMD) and acute megakaryoblastic leukemia (AMKL), many questions regarding these disorders remain unresolved. First, what is the relationship between TMD and AMKL? Second, what specific genetic alterations contribute to the leukemic process? Finally, what factors...

Topics

• Child
• DNA-Binding Proteins
• Down Syndrome
• Erythroid-Specific DNA-Binding Factors
• GATA1 Transcription Factor
• Genetic Predisposition to Disease
• Humans
• Leukemia, Megakaryoblastic, Acute
• Mutation
• Myeloproliferative Disorders