Article
Transcription factor GATA-1 and Down syndrome leukemogenesis.
Leukemia & lymphoma - 1 Jun 2006
Muntean Andrew G, Ge Yubin, Taub Jeffrey W, Crispino John D
Abstract excerpt
Mutations in transcription factors constitute one means by which normal hematopoietic progenitors are converted to leukemic stem cells. Recently, acquired mutations in the megakaryocytic regulator GATA1 have been found in essentially all cases of acute megakaryoblastic leukemia (AMkL) in children with Down syndrome and in the closely related malignancy transient myeloproliferative disorder. In all cases,...
Topics
- DNA
- Down Syndrome
- GATA1 Transcription Factor
- Humans
- Leukemia, Megakaryoblastic, Acute
- Models, Biological
- Mutation
- Myeloproliferative Disorders
- Protein Binding
- Sensitivity and Specificity
- Stem Cells