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Article

Trisomy 21 enhances human fetal erythro-megakaryocytic development

24 Sept 2008

Abstract excerpt

Children with Down syndrome exhibit 2 related hematopoietic diseases: transient myeloproliferative disorder (TMD) and acute megakaryoblastic leukemia (AMKL). Both exhibit clonal expansion of blasts with biphenotypic erythroid and megakaryocytic features and contain somatic GATA1 mutations. While altered GATA1 inhibits erythro-megakaryocytic development, less is known about how trisomy 21 impacts blood formation,...

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PMID: 18812473
DOI: 10.1182/blood-2008-05-157859

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