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Article

Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation

30 Jun 2013

Abstract excerpt

About 10% of Down syndrome (DS) infants are born with a transient myeloproliferative disorder (DS-TMD) that spontaneously resolves within the first few months of life. About 20%-30% of these infants subsequently develop acute megakaryoblastic leukemia (DS-AMKL). Somatic mutations leading to the exclusive production of a short GATA1 isoform (GATA1s) occur in all cases of DS-TMD and DS-AMKL. Mice engineered to...

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PMID: 23863621
DOI: 10.1172/jci40609

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