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Article

Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2021

Bradshaw Lucy E, Haines Rachel H, Thomas Kim S, Chalmers Joanne R, Irvine Alan D, Williams Hywel C, Brown Sara J

Abstract excerpt

BACKGROUND: Palmar hyperlinearity is a feature of ichthyosis vulgaris, the monogenic skin disorder caused by FLG loss-of-function mutations. OBJECTIVE: To investigate how well the presence or absence of hyperlinear palms (HLP) detect FLG genotype in children. METHODS: STARD criteria are used to report this diagnostic accuracy study. Phenotype and genotype data (four most prevalent FLG null mutations) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34608691
DOI: 10.1111/cea.14025

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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