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Article

Thymus-specific deletion of insulin induces autoimmune diabetes.

The EMBO journal - 16 Sept 2009

Fan Yong, Rudert William A, Grupillo Maria, He Jing, Sisino Giorgia, Trucco Massimo

Abstract excerpt

Insulin expression in the thymus has been implicated in regulating the negative selection of autoreactive T cells and in mediating the central immune tolerance towards pancreatic beta-cells. To further explore the function of this ectopic insulin expression, we knocked out the mouse Ins2 gene specifically in the Aire-expressing medullary thymic epithelial cells (mTECs), without affecting its expression in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19680229
DOI: 10.1038/emboj.2009.212
PMCID: PMC2750011

Genes

TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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