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Article

Genetic lesions in T‐cell tolerance and thresholds for autoimmunity

16 Mar 2005

Abstract excerpt

The cause of common organ-specific autoimmune diseases is poorly understood because of genetic and cellular complexity in humans and animals. Recent advances in the understanding of the mechanisms of the defects underlying autoimmune disease in autoimmune polyendocrinopathy syndrome type 1 and non-obese diabetic mice suggest that failures in central tolerance play a key role in predisposition towards...

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Identifiers

PMID: 15790352
DOI: 10.1111/j.0105-2896.2005.00253.x

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