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Telomeres in cancer and ageing

29 Nov 2010

Abstract excerpt

Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG repeats) bound to an array of specialized proteins. The length of telomere repeats and the integrity of telomere-binding proteins are both important for telomere protection. Furthermore, telomere length and integrity are regulated by a number of epigenetic...

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Share to Genetics, Aging, and Longevity in Model Organisms
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Identifiers

PMID: 21115533
DOI: 10.1098/rstb.2010.0291

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