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Article

Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptor.

Journal of neurochemistry - 1 Jul 2021

Asuni Gino P, Speidell Andrew, Mocchetti Italo

Abstract excerpt

Morphine withdrawal evokes neuronal apoptosis through mechanisms that are still under investigation. We have previously shown that morphine withdrawal increases the levels of pro-brain-derived neurotrophic factor (BDNF), a proneurotrophin that promotes neuronal apoptosis through the binding and activation of the pan-neurotrophin receptor p75 (p75NTR). In this work, we sought to examine whether morphine withdrawal...

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Identifiers

PMID: 33742683
DOI: 10.1111/jnc.15355
PMCID: PMC10176599

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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