Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.

Nucleic acids research - 1 Oct 2009

Bernstein N K, Hammel M, Mani R S, Weinfeld M, Pelikan M, Tainer J A, Glover J N M

Abstract excerpt

Mammalian polynucleotide kinase (mPNK) is a critical DNA repair enzyme whose 5'-kinase and 3'-phoshatase activities function with poorly understood but striking specificity to restore 5'-phosphate/3'-hydroxyl termini at sites of DNA damage. Here we integrated site-directed mutagenesis and small-angle X-ray scattering (SAXS) combined with advanced computational approaches to characterize the conformational...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to DNA
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutation

Share to Protein Binding

Share to Protein Structure, Tertiary

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 19671525
DOI: 10.1093/nar/gkp597
PMCID: PMC2764422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.PMID 19671525Read ↗

The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.Semantic proximity Read ↗

Characterization of DNA Substrate Binding to the Phosphatase Domain of the DNA Repair Enzyme Polynucleotide Kinase/Phosphatase.Semantic proximity Read ↗

Mechanism of RNA 2',3'-cyclic phosphate end healing by T4 polynucleotide kinase-phosphatase.Semantic proximity Read ↗

Mutational analysis of the 5'-OH oligonucleotide phosphate acceptor site of T4 polynucleotide kinase.Semantic proximity Read ↗

Structural insights into the role of DNA-PK as a master regulator in NHEJSemantic proximity Read ↗

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.Semantic proximity Read ↗

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNASemantic proximity Read ↗

Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.Semantic proximity Read ↗

Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.Semantic proximity Read ↗

Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents.Semantic proximity Read ↗

Activity and Function in Human Cells of the Evolutionary Conserved Exonuclease Polynucleotide Phosphorylase.Semantic proximity Read ↗

DNA Ligases: Progress and ProspectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.