Article
Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.
Molecular and cellular biology - 1 Jun 2014
Neal Jessica A, Sugiman-Marangos Seiji, VanderVere-Carozza Pamela, Wagner Mike, Turchi John, Lees-Miller Susan P, Junop Murray S, Meek Katheryn
Abstract excerpt
DNA-dependent protein kinase (DNA-PK) orchestrates DNA repair by regulating access to breaks through autophosphorylations within two clusters of sites (ABCDE and PQR). Blocking ABCDE phosphorylation (by alanine mutation) imparts a dominant negative effect, rendering cells hypersensitive to agents that cause DNA double-strand breaks. Here, a mutational approach is used to address the mechanistic basis of this...
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