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Article

Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2004

Rasouli-Nia Aghdass, Karimi-Busheri Feridoun, Weinfeld Michael

Abstract excerpt

Human polynucleotide kinase (hPNK) is a 57.1-kDa monomeric protein with conserved motifs associated with phosphatase and kinase activities. hPNK catalyzes phosphorylation of 5'-DNA termini and dephosphorylation of 3'-DNA termini. Previous studies, employing cell-free systems, have suggested that hPNK participates in the repair of DNA strand breaks. To better define the cellular function of hPNK, a double-stranded...

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Identifiers

PMID: 15100409
DOI: 10.1073/pnas.0400099101
PMCID: PMC406440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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