Article
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
Nucleic acids research - 1 Nov 2011
Zolner Angela E, Abdou Ismail, Ye Ruiqiong, Mani Rajam S, Fanta Mesfin, Yu Yaping, Douglas Pauline, Tahbaz Nasser, Fang Shujuan, Dobbs Tracey, Wang Chen, Morrice Nick, Hendzel Michael J, Weinfeld Michael, Lees-Miller Susan P
Abstract excerpt
Human polynucleotide kinase/phosphatase (PNKP) is a dual specificity 5'-DNA kinase/3'-DNA phosphatase, with roles in base excision repair, DNA single-strand break repair and non-homologous end joining (NHEJ); yet precisely how PNKP functions in the repair of DNA double strand breaks (DSBs) remains unclear. We demonstrate that PNKP is phosphorylated by the DNA-dependent protein kinase (DNA-PK) and...
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