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Article

Characterization of DNA Substrate Binding to the Phosphatase Domain of the DNA Repair Enzyme Polynucleotide Kinase/Phosphatase.

Biochemistry - 28 Mar 2017

Havali-Shahriari Zahra, Weinfeld Michael, Glover J N Mark

Abstract excerpt

Polynucleotide kinase/phosphatase (PNKP) is a DNA strand break repair enzyme that uses separate 5' kinase and 3' phosphatase active sites to convert damaged 5'-hydroxyl/3'-phosphate strand termini to ligatable 5'-phosphate/3'-hydroxyl ends. The phosphatase active site has received particular attention as a target of inhibition in cancer therapy development. The phosphatase domain dephosphorylates a range of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphotransferases (Alcohol Group Acceptor)

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Source

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Identifiers

PMID: 28276686
DOI: 10.1021/acs.biochem.6b01236
PMCID: PMC5469602

Genes

PNKP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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