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Article

Activity and Function in Human Cells of the Evolutionary Conserved Exonuclease Polynucleotide Phosphorylase.

International journal of molecular sciences - 31 Jan 2022

Falchi Federica A, Pizzoccheri Roberto, Briani Federica

Abstract excerpt

Polynucleotide phosphorylase (PNPase) is a phosphorolytic RNA exonuclease highly conserved throughout evolution. Human PNPase (hPNPase) is located in mitochondria and is essential for mitochondrial function and homeostasis. Not surprisingly, mutations in the PNPT1 gene, encoding hPNPase, cause serious diseases. hPNPase has been implicated in a plethora of processes taking place in different cell compartments and...

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Identifiers

PMID: 35163574
DOI: 10.3390/ijms23031652
PMCID: PMC8836086

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