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Article

The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.

Molecular cell - 4 Nov 2011

Garces Fernando, Pearl Laurence H, Oliver Antony W

Abstract excerpt

Mammalian polynucleotide kinase 3' phosphatase (PNK) plays a key role in the repair of DNA damage, functioning as part of both the nonhomologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar...

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Identifiers

PMID: 22055185
DOI: 10.1016/j.molcel.2011.08.036
PMCID: PMC4820033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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