Article
Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53.
British journal of cancer - 22 Apr 2008
Szybka M, Zawlik I, Kulczycka D, Golanska E, Jesien E, Kupnicka D, Stawski R, Piaskowski S, Bieniek E, Zakrzewska M, Kordek R, Liberski P P, Rieske P
Abstract excerpt
We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.
Topics
- Adolescent
- Adult
- Aged
- Brain Neoplasms
- Female
- Genes, p53
- Glioblastoma
- Humans
- Loss of Heterozygosity
- Male
- Middle Aged
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger