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Article

The role of DNA replication in chromosome condensation.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 May 2002

Pflumm Michelle F

Abstract excerpt

At metaphase, DNA in a human chromosome is estimated to be compacted at least 10,000 fold in length. However, the higher order mechanisms by which the chromosomes are organized in interphase and subsequently further condensed in mitosis have largely remained elusive. One generally overlooked participant in chromosome condensation is DNA replication. Many early studies of eukaryotic chromosome organization and...

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PMID: 12001264
DOI: 10.1002/bies.10092

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