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Identification of rare missense variants of ionotropic glutamate receptor N-methyl- D -aspartate 2 genes in patients with schizophrenia.

Psychiatric genetics - 1 Sept 2026

Wu Chia-Liang, Hu Tsung-Ming, Hsu Shih-Hsin, Tsai Hsin-Yao, Cheng Min-Chih

Abstract excerpt

Schizophrenia is a chronic mental disorder characterized by abnormal synaptic connectivity. N-methyl- D -aspartate receptors (NMDARs) are essential for synaptic transmission and plasticity, and rare variants in the genes encoding NMDARs are linked to neurodevelopmental disorders. In this study, we examined rare pathogenic mutations in four GRIN2 genes, which encode the NMDAR subunit 2, in patients with...

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PMID: 42253117
DOI: 10.1097/YPG.0000000000000423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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