Article
A population-specific uncommon variant in GRIN3A associated with schizophrenia.
Biological psychiatry - 15 Mar 2013
Takata Atsushi, Iwayama Yoshimi, Fukuo Yasuhisa, Ikeda Masashi, Okochi Tomo, Maekawa Motoko, Toyota Tomoko, Yamada Kazuo, Hattori Eiji, Ohnishi Tetsuo, Toyoshima Manabu, Ujike Hiroshi, Inada Toshiya, Kunugi Hiroshi, Ozaki Norio, Nanko Shinichiro, Nakamura Kazuhiko, Mori Norio, Kanba Shigenobu, Iwata Nakao, Kato Tadafumi, Yoshikawa Takeo
Abstract excerpt
BACKGROUND: Genome-wide association studies have successfully identified several common variants showing robust association with schizophrenia. However, individually, these variants only produce a weak effect. To identify genetic variants with larger effect sizes, increasing attention is now being paid to uncommon and rare variants. METHODS: From the 1000 Genomes Project data, we selected 47 candidate single...
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