Article
Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2009
Alexander Eric T, Weibel Ginny L, Joshi Michelle R, Vedhachalam Charulatha, de la Llera-Moya Margarita, Rothblat George H, Phillips Michael C, Rader Daniel J
Abstract excerpt
OBJECTIVE: To compare the abilities of human wild-type apoA-I (WT apoA-I) and human apoA-I(Milano) (apoA-I(M)) to promote macrophage reverse cholesterol transport (RCT) in apoA-I-null mice infected with adeno-associated virus (AAV) expressing either WT apoA-I or apoA-I(M). METHODS AND RESULTS: WT apoA-I- or apoA-I(M)-expressing mice were intraperitoneally injected with [H(3)]cholesterol-labeled J774 mouse...
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