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Article

Functional LCAT is not required for macrophage cholesterol efflux to human serum.

Atherosclerosis - 1 May 2009

Calabresi Laura, Favari Elda, Moleri Elsa, Adorni Maria Pia, Pedrelli Matteo, Costa Sara, Jessup Wendy, Gelissen Ingrid C, Kovanen Petri T, Bernini Franco, Franceschini Guido

Abstract excerpt

OBJECTIVES: To evaluate the capacity of serum from carriers of LCAT gene mutations to promote cell cholesterol efflux through the ABCA1, ABCG1, and SR-BI pathways. METHODS: Serum was obtained from 41 carriers of mutant LCAT alleles (14 carriers of two mutant LCAT alleles and 27 heterozygotes) and 10 non-carrier relatives (controls). The capacity of serum to promote cholesterol efflux was tested in...

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Source

Identifiers

PMID: 18922527
DOI: 10.1016/j.atherosclerosis.2008.08.038

Genes

LCAT
ABCA1
ABCG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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