Article
In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1.
Journal of lipid research - 1 Jul 2013
Holleboom Adriaan G, Jakulj Lily, Franssen Remco, Decaris Julie, Vergeer Menno, Koetsveld Joris, Luchoomun Jayraz, Glass Alexander, Hellerstein Marc K, Kastelein John J P, Hovingh G Kees, Kuivenhoven Jan Albert, Groen Albert K, Turner Scott M, Stroes Erik S G
Abstract excerpt
Atheroprotection by high density lipoprotein (HDL) is considered to be mediated through reverse cholesterol transport (RCT) from peripheral tissues. We investigated in vivo cholesterol fluxes through the RCT pathway in patients with low plasma high density lipoprotein cholesterol (HDL-c) due to mutations in APOA1. Seven carriers of the L202P mutation in APOA1 (mean HDL-c: 20 ± 19 mg/dl) and seven unaffected...
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