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Article

Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2011

Lee-Rueckert Miriam, Silvennoinen Reija, Rotllan Noemi, Judström Ilona, Blanco-Vaca Francisco, Metso Jari, Jauhiainen Matti, Kovanen Petri T, Escola-Gil Joan Carles

Abstract excerpt

OBJECTIVE: Chymase released by activated mast cells degrades high-density lipoproteins. We evaluated whether local activation of mast cells would attenuate cholesterol efflux from neighboring macrophage foam cells, thereby disrupting the entire in vivo pathway of macrophage-specific reverse chole...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21212401
DOI: 10.1161/ATVBAHA.110.221069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21212401-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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