Article
Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor.
Journal of lipid research - 1 Sept 2004
Nassir Fatiha, Xie Yan, Patterson Bruce W, Luo Jianyang, Davidson Nicholas O
Abstract excerpt
Recent studies have examined the role of the LDL receptor (LDLR) in regulating murine hepatic lipoprotein production and apolipoprotein B (apoB) secretion, with divergent conclusions from in vivo versus in vitro approaches. We have re-examined this question, both in vivo and in vitro, using apobec-1-/- mice to model the pattern of human hepatic apoB-100 secretion. Hepatic triglyceride production in vivo (using...
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