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Article

Comparative Effects of Diet-Induced Lipid Lowering Versus Lipid Lowering Along With Apo A-I Milano Gene Therapy on Regression of Atherosclerosis.

Journal of cardiovascular pharmacology and therapeutics - 1 May 2016

Wang Lai, Tian Fang, Arias Ana, Yang Mingjie, Sharifi Behrooz G, Shah Prediman K

Abstract excerpt

Apolipoprotein A-1 (Apo A-I) Milano, a naturally occurring Arg173to Cys mutant of Apo A-1, has been shown to reduce atherosclerosis in animal models and in a small phase 2 human trial. We have shown the superior atheroprotective effects of Apo A-I Milano (Apo A-IM) gene compared to wild-type Apo A-I gene using transplantation of retrovirally transduced bone marrow in Apo A-I/Apo E null mice. In this study, we...

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PMID: 26499098
DOI: 10.1177/1074248415610216

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Comparative Effects of Diet-Induced Lipid Lowering Versus Lipid Lowering Along With Apo A-I Milano Gene Therapy on Regression of Atherosclerosis.PMID 26499098Read ↗

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