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Article

Identification of new human CYP2C19 alleles (CYP2C196 and CYP2C192B) in a Caucasian poor metabolizer of mephenytoin.

The Journal of pharmacology and experimental therapeutics - 1 Sept 1998

Ibeanu G C, Goldstein J A, Meyer U, Benhamou S, Bouchardy C, Dayer P, Ghanayem B I, Blaisdell J

Abstract excerpt

A genetic polymorphism in the metabolism of the anticonvulsant drug S-mephenytoin has been attributed to defective CYP2C19 alleles. This genetic polymorphism displays large interracial differences with the poor metabolizer (PM) phenotype representing 2-5% of Caucasian and 13-23% of Oriental popul...

Topics

Alleles
Anticonvulsants
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Humans
Mephenytoin
Mixed Function Oxygenases
Mutagenesis, Site-Directed
White People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 9732415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9732415-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin.PMID 9732415Read ↗

A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.Semantic proximity Read ↗

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians.Semantic proximity Read ↗

Identification and functional characterization of new potentially defective alleles of human CYP2C19.Semantic proximity Read ↗

A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin.Semantic proximity Read ↗

Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world.Semantic proximity Read ↗

Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole.Semantic proximity Read ↗

Biochemistry and molecular biology of the human CYP2C subfamily.Semantic proximity Read ↗

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations.Semantic proximity Read ↗

Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4'-hydroxylation and omeprazole 5'-hydroxylation.Semantic proximity Read ↗

Novel mutations in the cytochrome P450 2C19 gene: a pitfall of the PCR-RFLP method for identifying a common mutation.Semantic proximity Read ↗

Genetic polymorphism of (S)-mephenytoin 4'-hydroxylation in populations of African descent.Semantic proximity Read ↗

Clinical Application of CYP2C19 Pharmacogenetics Toward More Personalized MedicineSemantic proximity Read ↗

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