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Article

High incidence of coding gene mutations in mitochondrial DNA in esophageal cancer.

Molecular medicine reports - 1 Dec 2017

Liu Zong-Wen, Guo Zhen-Jiang, Chu A-Lan, Zhang Yan, Liang Bing, Guo Xing, Chai Ting, Song Rui, Hou Ge, Yuan Jin-Jin

Abstract excerpt

The aim of the present study was to detect mutations in the coding genes of mitochondrial DNA (mtDNA) in three esophageal cancer cell lines and in tumor tissues obtained from 30 patients with esophageal cancer, to investigate the relationship between protein‑ and RNA‑coding gene mutations and esophageal cancer. mtDNA was extracted and the coding genes were sequenced and analyzed by comparing the sequencing...

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Identifiers

PMID: 28990096
DOI: 10.3892/mmr.2017.7663

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