Gene mutations of acute myeloid leukemia in the genome era.

Abstract excerpt

Ten years ago, gene mutations found in acute myeloid leukemia (AML) were conceptually grouped into class I mutation, which causes constitutive activation of intracellular signals that contribute to the growth and survival, and class II mutation, which blocks differentiation and/or enhance self-renewal by altered transcription factors. A cooperative model between two classes of mutations has been suggested by...

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• Cell Cycle Proteins
• Chromosomal Proteins, Non-Histone
• Co-Repressor Proteins
• Cohesins
• Epigenesis, Genetic