Parallel targeted next generation sequencing of childhood and adult acute myeloid leukemia patients reveals uniform genomic profile of the disease.

doi:10.1007/s13277-016-5142-7

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Article

Parallel targeted next generation sequencing of childhood and adult acute myeloid leukemia patients reveals uniform genomic profile of the disease.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2016

Marjanovic Irena, Kostic Jelena, Stanic Bojana, Pejanovic Nadja, Lucic Bojana, Karan-Djurasevic Teodora, Janic Dragana, Dokmanovic Lidija, Jankovic Srdja, Vukovic Nada Suvajdzic, Tomin Dragica, Perisic Ognjen, Rakocevic Goran, Popovic Milos, Pavlovic Sonja, Tosic Natasa

Abstract excerpt

The age-specific differences in the genetic mechanisms of myeloid leukemogenesis have been observed and studied previously. However, NGS technology has provided a possibility to obtain a large amount of mutation data. We analyzed DNA samples from 20 childhood (cAML) and 20 adult AML (aAML) patients, using NGS targeted sequencing. The average coverage of high-quality sequences was 2981 × per amplicon. A total of...

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Identifiers

PMID: 27460089
DOI: 10.1007/s13277-016-5142-7

Genes

IDH1
IDH2
ABL1
EGFR
GNAQ
JAK3
NPM1
SMARCB1

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Source receipt: pubmed, retrieved 6 Sept 2026.

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