Article
Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing.
Leukemia - 1 May 2011
Greif P A, Eck S H, Konstandin N P, Benet-Pagès A, Ksienzyk B, Dufour A, Vetter A T, Popp H D, Lorenz-Depiereux B, Meitinger T, Bohlander S K, Strom T M
Abstract excerpt
Genetic lesions are crucial for cancer initiation. Recently, whole genome sequencing, using next generation technology, was used as a systematic approach to identify mutations in genomes of various types of tumors including melanoma, lung and breast cancer, as well as acute myeloid leukemia (AML). Here, we identify tumor-specific somatic mutations by sequencing transcriptionally active genes. Mutations were...
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