Article
Mitochondrial gene mutation: the ageing process and degenerative diseases.
Biochemistry international - 1 Dec 1990
Linnane A W, Baumer A, Maxwell R J, Preston H, Zhang C F, Marzuki S
Abstract excerpt
Polymerase chain reaction (PCR) amplification was carried out on total DNA from a range of autopsy tissues from deceased human subjects with no known mitochondrial disease, aged from birth (80 minutes) to 87 years. We report the finding of an age-related 5 kb deletion in the mitochondrial genomes of these subjects. The deletion occurs between nucleotide positions 8470 and 13459 of the mitochondrial genome, and is...
Topics
- Adenosine Triphosphatases
- Adult
- Aged
- Aged, 80 and over
- Aging
- Base Sequence
- Chromosome Deletion
- DNA, Mitochondrial
- Electron Transport Complex IV
- Electrophoresis, Agar Gel
- Female