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Article

Genetic and functional changes in mitochondria associated with aging.

Physiological reviews - 1 Apr 1997

Ozawa T

Abstract excerpt

This review is devoted to the molecular genetics and bioenergetics of human mitochondria related to the mechanism of aging. Morphological and functional changes of mitochondria associated with age and age-related disease are overviewed with special reference to the changes in enzymes encoded by mitochondrial-inherent genome. The somatically acquired mutations and oxidative damage of the genome, which lead an...

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PMID: 9114820
DOI: 10.1152/physrev.1997.77.2.425

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