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Article

Detection of a specific mitochondrial DNA deletion in tissues of older humans.

Nucleic acids research - 11 Dec 1990

Cortopassi G A, Arnheim N

Abstract excerpt

Using PCR, we found that normal heart muscle and brain from adult human individuals contain low levels of a specific mitochondrial DNA deletion, previously found only in patients affected with certain types of neuromuscular disease. This deletion was not observed in fetal heart or brain. Experimental tests support the idea that the deletion exists in vivo in adult mitochondria and is not an in vitro artifact of...

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Identifiers

PMID: 2263455
DOI: 10.1093/nar/18.23.6927
PMCID: PMC332752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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