Article
Detection of a specific mitochondrial DNA deletion in tissues of older humans.
Nucleic acids research - 11 Dec 1990
Cortopassi G A, Arnheim N
Abstract excerpt
Using PCR, we found that normal heart muscle and brain from adult human individuals contain low levels of a specific mitochondrial DNA deletion, previously found only in patients affected with certain types of neuromuscular disease. This deletion was not observed in fetal heart or brain. Experime...
Topics
- Adult
- Aging
- Base Sequence
- Brain
- Brain Chemistry
- DNA, Mitochondrial
- Female
- Fetal Death
- Fetal Heart
- Humans
- Infant, Newborn
- Male
- Middle Aged
- Mitochondria, Heart
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Reference Values