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Article

Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology.

Cytoskeleton (Hoboken, N.J.) - 1 Jul 2012

Slepak Tatiana I, Salay Lindsey D, Lemmon Vance P, Bixby John L

Abstract excerpt

In a neuronal overexpression screen focused on kinases and phosphatases, one "hit" was the dual specificity tyrosine phosphorylation-regulated kinase (Dyrk4), which increased the number of dendritic branches in hippocampal neurons. Overexpression of various Dyrk family members in primary neurons significantly changed neuronal morphology. Dyrk1A decreased axon growth, Dyrk3 and Dyrk4 increased dendritic branching,...

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Identifiers

PMID: 22359282
DOI: 10.1002/cm.21021
PMCID: PMC3556588

Genes

DCX

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Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology.PMID 22359282Read ↗

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