Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genes with internal repeats require the THO complex for transcription.

Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2006

Voynov Vladimir, Verstrepen Kevin J, Jansen An, Runner Vanessa M, Buratowski Stephen, Fink Gerald R

Abstract excerpt

The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes, is required for the efficient expression of FLO11 and other yeast genes that have long internal tandem repeats. FLO11 transcription elongation in Tho- mutants is hindered in the region of the tandem repeats, resulting in a loss of function. Moreover, the repeats become genetically unstable in Tho- mutants. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Multiprotein Complexes

Share to Open Reading Frames

Share to Repetitive Sequences, Nucleic Acid

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16983072
DOI: 10.1073/pnas.0606546103
PMCID: PMC1599979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genes with internal repeats require the THO complex for transcription.PMID 16983072Read ↗

The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.Semantic proximity Read ↗

A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination.Semantic proximity Read ↗

Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p.Semantic proximity Read ↗

Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Semantic proximity Read ↗

Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein.Semantic proximity Read ↗

Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.Semantic proximity Read ↗

Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.Semantic proximity Read ↗

Mutations in the DNA processivity factor POL30 predispose the FLO11 locus to epigenetic instability in S. cerevisiae.Semantic proximity Read ↗

Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity.Semantic proximity Read ↗

Molecular evidence for a positive role of Spt4 in transcription elongation.Semantic proximity Read ↗

New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.Semantic proximity Read ↗

Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.