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Article

DNA profiling analysis of 100 consecutive de novo acute myeloid leukemia cases reveals patterns of genomic instability that affect all cytogenetic risk groups.

Leukemia - 1 Jun 2007

Suela J, Alvarez S, Cifuentes F, Largo C, Ferreira B I, Blesa D, Ardanaz M, García R, Marquez J A, Odero M D, Calasanz M J, Cigudosa J C

Abstract excerpt

We have carried out a high-resolution whole genome DNA profiling analysis on 100 bone marrow samples from a consecutive series of de novo acute myeloid leukemia (AML) cases. After discarding copy number changes that are known to be genetic polymorphisms, we found that genomic aberrations (GA) in the form of gains or losses of genetic material were present in 74% of the samples, with a median of 2 GA per case...

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PMID: 17377590
DOI: 10.1038/sj.leu.2404653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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